Reference Series
why is platinum resistant to corrosion with reference to reduction potentials and the electrochemical series?
Platinum is an inert metal which means that it does not reduce or oxidize.
Because the center channel speaker reproduces more than 60 percent of a movie soundtrack, Klipsch spared no expense when developing the Reference Series RC-52. With its ideal combination of technology, performance and design, this speaker delivers a seamless, engaging soundstage that puts listeners inside the action...
|
|
Db Link Nf103 Reference Series Ground Loop Isolator
|
|
What does the i stand for in the new RS1i from Grado? Improved, that's what! Featuring a new species of handcrafted Mahogany earpieces made using an intricate curing process; Grado has been able to optimize the tonal quality...
|
|
This Klipsch Home Theater Speaker package is a great sounding system. Consisting of Klipsch's newest line you will get 1 RC52II Center Channel Speaker, 2 RF52II Floor Standing Speakers, 2 RB51II Bookshelf Speakers and the SW-350 subwoofer...
|
|
Are you getting all the sound you crave from your stereo or home-theater sound system? Think about the Klipsch RF-52 Reference Series Floorstanding Loudspeaker. An ideal combination of technology, performance and design, the Reference Series RF-52 delivers a level of realism and subtlety that's beyond anything you've heard before...
|
|
If you want high definition for your HD content, games and Blu-ray entertainment, there's nothing better than 1080p Full HD. And if you want sports and fast action to be as a crisp as they are exciting, TruMotion 120Hz virtually loses the blur and keeps the sizzle...
|
|
Db Link Hlc2 Reference Series High/Low Converter
|
|
Brand New Boston Acoustics GT Reference Series GT-2300 2-Channel 1400 Watt RMS Class AB Car Amplifier with Red LED Power Badge and Orange Protect Indicator
Features
Boston Acoustics GT-2300 Reference Series Car Amplifier
2-channel car amplifier
2 Ch...
|
|
The AKG Q701 reference-class premium headphones represent a momentous partnership with AKG and one of the most accomplished musicians of the 20th century: Quincy Jones an American icon whose productions include the best-selling album (Thriller) and single ("We Are the World") of all time...
|
|
Infinity's 860w 8-inch Single Voice Coil Subwoofer makes the perfect upgrade to your factory system or where space is an issue. The Infinity Reference Series Infinity's Reference Series has been engineered to deliver best-in-class performance for those looking to replace or upgrade their factory speakers...
|
|
Toll-like receptor 5 (TLR5), a member of the evolutionarily conserved Toll-like receptor family, has evolved to permit mammals specifically to detect flagellated bacterial pathogens. Like all other members of the TLR family, TLR5 is composed of an extracellular domain containing multiple leucine-rich repeats (LRRs), a transmembrane region, and a cytoplasmic tail containing the conserved TIR domain. The TLR5 gene has been mapped to chromosome 1q41-42. The gene encodes a putative 858 aminio acid protein with a calculated molecular weight of 91 kDa. It is most closely related to TLR3 with 26% overall amino acid sequence identity.
In vivo, TLR5 mRNA is expressed as a single transcript in ovary, prostate. In vitro, TLR5 is most significantly upregulated in PMA-differentiated THP-1 cells by autocrine IL-6, IL-10, and TNF-α, but is also elevated by IFN-γβ. Further, TLR5 mRNA expression is elevated after exposure to both Gram-positive and Gram-negative bacteria. Ex vivo, however, granulocyte and in particular monocyte TLR5 expression is downregulated upon exposure to Gram-negative bacteria (1, 2).
TLR5 is expressed in epithelial cells of the airways, intestine, and urogenital tract, as well as on hemopoietic cells of the innate and adaptive immune system and has recently been shown to be involved in the transport of flagellated Salmonella typhimurium from the intestinal tract to the mesenteric lymph nodes. Like other described TLRs, TLR5 utilizes the adaptor protein MyD88 and IL-1 receptor-associated kinase (IRAK) to activate a signal transduction cascade that results in the activation of the transcription factor NF-B necessary for flagellin-induced effects on gene expression (4). TLR5 forms a homodimer as well as a heterodimer with TLR4. Both complexes function to recognize the Flagellin protein of both Gram-positive and Gram-negative bacteria, and activation of the receptor mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha production. TheTLR5 recognition site on flagellin is conserved among a wide variety of flagellated bacteria although select bacterial species possess unique flagellin molecules that evade TLR5 recognition. These amino acids are located in the highly conserved D1 domain of the flagellin protein and cluster on the convex surface that contacts adjacent flagellin monomers in the flagellar protofilament. Mutating individual residues in the TLR5 recognition site significantly reduced or completely abolished bacterial motility, suggesting that evolving a functional flagellin that evades TLR5 would require a complex series of mutations (5).
Reference:
1. Zarember, K.A. & P.J. Godowski (2002) J. Immunol. 168:554.
2. Muzio, M. et al. (2000) J. Immunol. 164:5998.
3. Yimin Yu Am J Physiol Gastrointest Liver Physiol 285: G282-G290, 2003
4. Nature. 2001 Apr 26;410(6832):1099-103.
IMGENEX India Pvt Ltd. the only biotech company in Orissa and one of its kinds in Eastern India. IMGENEX India started in Oct as an outsourcing branch of
IMGENEX Corporation, San Diego, USA. Find out more information about
Toll-like receptors .
US $549.99
